Opis
✅ Active Ingredients
Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40 (Trade name: BPMed-BoLCA-Protein / BoLCa) — The world’s first botulinum-derived ingredient listed in the International Cosmetic Ingredient Dictionary (ICID). It is a recombinant protein material with a molecular weight of 53.6 kDa. It consists of the “light chain” protein of botulinum toxin and the MTD (Macromolecular Transmission Domain) protein, which acts as the “heavy chain” and enables direct penetration through the skin and into nerve cells. It cleaves the intracellular SNAP-25 structure, blocking neuromuscular transmission without paralyzing muscles.
Glycerin — A hygroscopic substance, meaning it binds and retains water molecules. Due to its relatively small size, it penetrates into the deep layers of the epidermis, intensely hydrating the skin.
Sodium Hyaluronate (Non-crosslinked hyaluronic acid) — Has strong and immediate water-binding properties, creating a specific water reservoir on the skin’s surface. By forming a protective film on the skin’s surface, it reduces transepidermal water loss and protects the skin against dryness and the adverse effects of external factors.
✅ Indications
Expression wrinkles
Static wrinkles that traditional botulinum toxin cannot improve
Deteriorated skin texture and lack of elasticity
Enlarged pores and excessive sebaceous gland secretion (excess sebum)
Acne requiring soothing
Skin requiring brightening and lifting
✅ Mechanism of Action
The preparation’s action is based on innovative permeability technology. The MTD (Macromolecular Transmission Domain) protein ensures the penetration of molecules through the epidermis and skin layer, reaching the neuronal cells without the need for injection into the muscle layer. In the target cell, the 53.6 kDa light chain cleaves the SNAP-25 protein (an intracellular neurotransmission structure), which inhibits the release of neurotransmitters. The expected efficacy mimics the effect of intradermal botulinum toxin injection (so-called Dermotoxin, MicroBotox, skin Botox), effectively smoothing the skin and reducing sebum, while maintaining full facial expression without a frozen face effect.
✅ Treatment Effects
Effective smoothing of expression and static wrinkles
Skin lifting
Improved elasticity and texture
Shrinking of pores and reduction of sebaceous gland secretion
Skin brightening
Soothing of acne symptoms
No muscle paralysis or stiffness of skin tissues
✅ Key Benefits
Needle-free cosmetological botox: Utilizes advanced cell penetration technology, enabling a smoothing effect without injections, bypassing the limitations of traditional botox.
World-scale innovation: The world’s first botulinum-derived ingredient registered in the ICID (International Cosmetic Ingredient Dictionary) and the European CosIng database.
Action on static wrinkles: Unlike traditional botulinum toxin, the innovative formula allows for effective improvement in the appearance of static wrinkles as well.
High safety: Cytotoxicity, mutation, and chromosome tests were successfully conducted in prestigious GLP laboratories in Korea and Germany (e.g., ATGC Lab., ChemOn GLP Lab).
Global patents: Patent registration has been completed in Korea, Japan, Russia, the United States, China, Canada, Brazil, India, the United Kingdom, Germany, and France.
Renowned manufacturer: The preparation is manufactured by DEXLEVO INC., an experienced producer of well-known products such as Gouri and POWER BOOSTER.











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