CaHa 30%

Opis

✅ Active Ingredients

Calcium Hydroxyapatite — CaHA (30%) A well-established ingredient with properties stimulating the production of type I and III collagen in the skin. The 30% CaHA concentration is identical to that in Radiesse, providing comparable volumetric and regenerative action. Does not migrate in the skin thanks to an innovative technology in which CaHA surrounds the cross-linked hyaluronic acid molecules — the specific molecular structure creates “ends” in the CaHA structure that stabilize the preparation at the injection site and minimize the risk of displacement within the tissues. CaHA naturally occurs in the body, serving as a scaffold for bone growth and the proliferation of stromal growth cells. It has been used in reconstructive dentistry and orthopedics before finding application in aesthetic medicine. Approved by KFDA for the treatment of moderate and deep wrinkles and folds, correction of lost jawline contour, restoration of hand dorsum volume, and HIV lipodystrophy therapy.

Sodium Hyaluronate — Cross-linked Hyaluronic Acid Increases the volumetric effect of the preparation compared to products containing only CaHA and CMC (carboxymethylcellulose). Improves skin hydration and elasticity, supporting tissue regeneration and revitalization. A key advantage over classic CaHA preparations: the presence of hyaluronic acid allows excess preparation to be corrected using hyaluronidase if needed.

Bioactive Peptides Potent collagen stimulators supporting skin regenerative processes. Act synergistically with CaHA, enhancing firming and rejuvenation effects.

✅ Indications

• Loss of collagen and skin elasticity on the face leading to weakening and wrinkle formation
• Visible signs of skin aging including loss of firmness and volume
• Need for fibroblast biostimulation to rebuild skin structure
• Cheek volumetry
• Jawline modeling
• Chin elongation
• Correction of soft tissue deficits
• Off-label: skin laxity of the face, neck, décolletage, arms, abdomen, buttocks, and thighs using diluted and hyperdiluted application

✅ Mechanism of Action

The preparation acts through a three-phase neocollagenesis process confirmed by histological and immunohistochemical studies.

Phase 1 — Initial Response and Immune System Stimulation: After injection into the skin, CaHA molecules form a stable matrix around the hyaluronic acid, which provides intensive hydration and improves the biomechanical properties of the skin. Immune system cells, particularly macrophages, migrate to surround the implant and initiate a controlled inflammatory response.

Phase 2 — Fibroblast Activation and Initial Collagen Synthesis: Macrophages trigger a signalling cascade that activates fibroblasts, leading to their proliferation and intensive synthesis of type III collagen — elastic, young fibres representing the first phase of neocollagenesis. Bioactive peptides present in the preparation support tissue regeneration, accelerating new collagen production and improving skin elasticity and structure.

Phase 3 — Gradual CaHA Biodegradation and Collagen Remodeling: CaHA molecules undergo gradual biodegradation, with macrophages absorbing and breaking down CaHA into calcium and phosphate ions that support skin mineral homeostasis. Type III collagen is gradually replaced by more stable and durable type I collagen, leading to long-term improvement of skin firmness and density.

Immediate volumetric effect: The preparation provides a 1:1 proportion for volumetric correction immediately after injection. Over the following 12 to 18 months, the CaHA matrix transforms into CaHA microspheres serving as a scaffold for collagen formation and stromal cell proliferation. HA is simultaneously resorbed by the body along with CaHA.

Collagen III expression note from source material: Belviso CaHA 30% contains 300 mg/ml. Based on referenced research data showing collagen III expression at 4.5 mg/ml concentration, the source material states that collagen III expression after application of this preparation is approximately 67 times greater than in that referenced study.

✅ Belviso CaHA 30% vs Radiesse — Key Differences

Belviso CaHA 30% contains 30% CaHA microspheres with cross-linked HA, while Radiesse contains 30% CaHA with CMC (carboxymethylcellulose).

Duration: Belviso CaHA 30% effects last 12 to 24 months according to source material. Radiesse effects last 12 to 18 months.

Correctability: Belviso CaHA 30% can be partially corrected with hyaluronidase due to the HA component. Radiesse cannot be dissolved — in case of complications it must be surgically removed or degraded with time.

Plasticity: Belviso CaHA 30% is more elastic and adaptable to tissues, better suited for dynamic facial areas. Radiesse has a stiffer consistency, best for deep volumetry and structural support.

Granuloma and nodule risk: Belviso CaHA 30% has a lower risk of polymer nodule formation due to better tissue integration and the absence of CMC. Radiesse has a possible risk of polymer nodules due to CMC, especially in dynamic areas.

Migration: Belviso CaHA 30% does not migrate, as CaHA forms a stable collagen matrix and HA provides better integration. Radiesse has low migration but possible irregularity in delicate areas.

Vascular safety: The presence of HA in Belviso CaHA 30% allows hyaluronidase treatment in case of vascular occlusion, providing an additional safety mechanism.

✅ Treatment Effects

• Immediate volumetric effect after injection
• Lasting increase in skin firmness and elasticity
• Natural restoration of facial volume and contour
• Gradual improvement of skin structure through long-term collagen stimulation
• Intensive hydration and nourishment of the skin thanks to HA
• Rejuvenating and smoothing effect lasting a long time
• Effects lasting 12 to 24 months according to source material

✅ Treatment Areas

• Cheeks and malar area
• Jawline
• Chin
• Soft tissue deficit correction areas
• Off-label: neck, décolletage, arms, abdomen, buttocks, thighs, hands

✅ Key Benefits

Correctability — key advantage over classic CaHA preparations: The presence of cross-linked HA allows excess product to be corrected with hyaluronidase, giving patients and practitioners greater safety and control over the outcome.

No CMC — superior plasticity and safety: The absence of carboxymethylcellulose makes Belviso CaHA 30% more plastic and less prone to polymer nodule formation in the skin compared to Radiesse.

Dual immediate and long-term action: Provides immediate 1:1 volumetric correction directly after injection, combined with a collagen regeneration process that continues over 12 to 18 months.

Three-phase neocollagenesis: The preparation triggers a confirmed biological process — immune stimulation, fibroblast activation and type III collagen synthesis, followed by type III to type I collagen remodeling — resulting in lasting structural skin improvement.

Broad application range — undiluted and diluted protocols: Can be used undiluted for volumetry and contouring, diluted 1:1 for microstructural correction, or hyperdiluted 1:3 for biostimulation of larger body areas including neck, décolletage, and hands.

Cannula recommended for safety: Due to the high CaHA concentration (30%), use of a 22G cannula (50 mm or 70 mm) is recommended for cheek volumetry and jawline modeling, covering a larger area with fewer entry points and reducing the risk of vascular injury.

✅ Post-Treatment Recommendations

• Avoid sun exposure and high temperatures for several days after treatment.
• Use gentle skincare as recommended by the specialist.
• Regularly hydrate the skin and protect against external factors.
• Monitor skin reaction after treatment to avoid potential adverse effects.
  

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  ✅ Storage

  Store at room temperature. Store in the shade to avoid direct sunlight. Do not refrigerate. Shelf life: 24 months.